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Multifocality in gallbladder cancer: An imaging-based study.

A B Pooja1, Daneshwari Kalage1, Chandra Shekhar Singh Aswal1

  • 1Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Clinical and Experimental Hepatology
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

Multifocal gallbladder cancer (GBC) is rare but impacts treatment. Imaging can help diagnose this condition, guiding management for unresectable cases.

Keywords:
CTMRIbiliary malignanciesgallbladder cancer

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Area of Science:

  • Oncology
  • Radiology
  • Gastroenterology

Background:

  • Gallbladder cancer (GBC) typically presents as solitary lesions.
  • Multifocal GBC can significantly affect surgical resectability and patient management.
  • Systematic imaging studies on GBC multifocality are lacking.

Purpose of the Study:

  • To evaluate the characteristics of multifocal gallbladder cancer using cross-sectional imaging.
  • To assess the prevalence and imaging findings of multifocal GBC.

Main Methods:

  • Retrospective analysis of contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) scans.
  • Inclusion of patients with histopathological or cytological GBC diagnosis.
  • Independent evaluation of multifocal disease findings by two radiologists.

Main Results:

  • Multifocal GBC was identified in 5.2% of patients (17 out of 324).
  • Common sites included gallbladder fundus and neck, or fundus and common bile duct.
  • Wall thickening was the most common morphology; most patients (70.6%) presented with unresectable disease.

Conclusions:

  • Multifocal gallbladder cancer, though rare, is identifiable through imaging.
  • Early imaging-based diagnosis can inform appropriate management strategies for GBC.