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MicroRNA biogenesis pathway alterations in aging
Jorge Sanz-Ros1,2, Cristina Mas-Bargues1, Nekane Romero-García1,3
1Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia 46010, Spain.
Extracellular Vesicles and Circulating Nucleic Acids
|December 19, 2024
Summary
Aging involves disrupted microRNA (miRNA) biogenesis, affecting gene regulation and leading to age-related diseases. Enhancing miRNA processing pathways may promote healthy aging and extend lifespan.
Area of Science:
- Molecular Biology
- Genetics
- Gerontology
Background:
- Aging is linked to genomic instability and altered gene expression.
- MicroRNAs (miRNAs) are key regulators of post-transcriptional gene expression.
- Dysregulation of miRNA biogenesis is implicated in the aging process.
Purpose of the Study:
- To investigate the impact of disrupted miRNA biogenesis on aging.
- To explore the role of key miRNA processing enzymes and complexes in aging.
- To connect miRNA biogenesis alterations with age-related conditions and lifespan.
Main Methods:
- Analysis of age-related changes in miRNA transcription and processing.
- Examination of the microprocessor complex (DGCR8/Drosha) and Dicer function during aging.
- Review of miRNA export mechanisms (Exportin-5) in the context of aging and senescence.
Main Results:
- Age-related genomic changes and epigenetic modifications affect primary miRNA (pri-miRNA) transcription.
- Alterations in microprocessor complex activity and Dicer expression impact miRNA profiles during aging.
- Interventions like caloric restriction influence microprocessor activity and are linked to lifespan extension.
Conclusions:
- Disrupted miRNA biogenesis is a significant factor in aging and age-related diseases.
- Targeting miRNA biogenesis pathways offers potential therapeutic strategies for healthy aging.
- Understanding miRNA processing is crucial for developing interventions to promote longevity.
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