Non-linear dose-response relationship between the visceral adiposity index and diabetes in adults with normoglycemia: a cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.The visceral adiposity index (VAI) is linked to increased diabetes risk in Japanese adults. Reducing VAI, especially below 4.67, may significantly lower the chances of developing type 2 diabetes.
Area Of Science
- Metabolic Health
- Diabetes Epidemiology
- Obesity Research
Background
- Previous research indicates a connection between visceral adiposity index (VAI) and diabetes.
- This study specifically investigates this association within a normoglycemic adult population in Japan.
Purpose Of The Study
- To examine the relationship between the visceral adiposity index (VAI) and the incidence of diabetes in Japanese adults.
- To determine if the association is linear or non-linear and assess the predictive value of VAI for diabetes development.
Main Methods
- A longitudinal cohort study (NAGALA) was conducted from 2004 to 2015 in Japan.
- Multivariate Cox regression, restricted cubic spline (RCS) models, and ROC curve analysis were employed.
- The study analyzed data from 15,452 normoglycemic adults.
Main Results
- A positive, non-linear association was found between VAI and incident diabetes (HR=1.13).
- An inflection point was observed at VAI=4.67; values below this showed a stronger association (HR=1.24 per unit increase).
- The association was more pronounced in women, and VAI demonstrated good predictive power (AUC=0.7479).
Conclusions
- The study confirms a positive, non-linear link between VAI and diabetes in Japanese adults.
- A VAI below 4.67 indicates a critical threshold where VAI reduction can significantly decrease diabetes risk.
- The findings highlight VAI as a valuable marker for diabetes risk, particularly in women.
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