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Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Murine Kidney Transplant Technique

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Published on: October 20, 2015

Push toward pre-emptive kidney transplantation - for sure?

Orsolya Cseprekal^1,2,3, Christian Jacquelinet^2,3, Ziad Massy^3,4,5

¹Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary.

Clinical Kidney Journal

|December 19, 2024

Summary

Pre-emptive kidney transplantation (PKT) may not always be best for end-stage chronic kidney disease (CKD) patients. Re-evaluating timing and indications is crucial for optimizing donor organ use and patient outcomes.

Keywords:

epidemiology kidney transplantation outcome pre-emptive risk estimation

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Last Updated: May 2, 2026

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Published on: October 20, 2015

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

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Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

Area of Science:

Nephrology
Transplantation Surgery
Public Health Policy

Background:

Pre-emptive kidney transplantation (PKT) is traditionally viewed as optimal for end-stage chronic kidney disease (CKD).
Increased transplant rates have strained donor organ availability and lengthened waitlists.
Current practices necessitate re-evaluating transplantation timing and indications.

Purpose of the Study:

To critically assess the universal benefit of PKT versus non-PKT or conservative management.
To highlight limitations of conventional predictive models in risk stratification for PKT.
To advocate for a refined discourse on optimal PKT timing and recipient selection.

Main Methods:

Review of retrospective analyses on PKT outcomes.
Analysis of limitations in existing predictive models for transplantation risk.
Discussion of clinical and societal perspectives on donor organ allocation.

Main Results:

Retrospective data suggest PKT may not always outperform non-PKT approaches.
Conventional models inadequately assess risks for specific patient subpopulations.
Potential for disparities in wait-listed patients due to inaccurate risk prediction.

Conclusions:

The universal benefit of PKT requires re-evaluation.
Improved predictive models are needed to optimize donor resource allocation and identify risks of 'unsuccessful' PKT.
Personalized treatment strategies acknowledging alternative therapies are critical for certain CKD patients.