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Permanent Cerebral Vessel Occlusion via Double Ligature and Transection

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Published on: July 21, 2013

Cervical Artery Tortuosity Is Associated With Dissection Occurrence and Late Recurrence: A Nested Case-Control Study.

Lukas Mayer-Suess¹, Michael Knoflach^1,2, Tamara Peball¹

¹Department of Neurology (L.M.-S., M.K., T.P., S.K., R.P.), Medical University of Innsbruck, Austria.

|December 19, 2024

Summary

This summary is machine-generated.

Cervical artery tortuosity is higher in patients with spontaneous cervical artery dissection, especially with recurrence. This measurable biomarker may indicate connective tissue disorders and predict dissection risk.

Keywords:

biopsy cerebrovascular disorders connective tissue magnetic resonance angiography vertebral artery

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Area of Science:

Vascular Medicine
Radiology
Genetics

Background:

Spontaneous cervical artery dissection (SCAD) pathogenesis is unclear, with no established recurrence predictors.
Cervical artery tortuosity, linked to connective tissue disorders, is investigated as a potential SCAD predictor.
The ReSect study aims to identify risk factors for recurrent cervical artery dissection.

Purpose of the Study:

To investigate the association between cervical artery tortuosity and spontaneous cervical artery dissection (SCAD).
To assess if tortuosity predicts SCAD recurrence.
To explore the link between tortuosity and proteomic markers of SCAD recurrence.

Main Methods:

Observational study (ReSect) of SCAD patients (1996-2018) with clinical/radiological follow-up.
Internal carotid and vertebral artery tortuosity assessed via 3D MRI angiography.
Statistical analyses (χ², Mann-Whitney U, Kruskal-Wallis, logistic regression) compared patients and controls, and recurrence status. Proteomic data analyzed for associations.

Main Results:

SCAD patients (n=125) showed significantly increased internal carotid artery tortuosity vs. controls (n=24; OR, 2.65).
Elevated tortuosity was more pronounced in patients with long-term recurrence (n=7; OR, 2.00).
In SCAD patients (n=37), tortuosity correlated with proteomic markers previously linked to dissection recurrence.

Conclusions:

Internal carotid artery tortuosity is elevated in SCAD patients, particularly those with recurrence.
Tortuosity, a measurable biomarker, may suggest subclinical connective tissue disease in SCAD patients.
The association between tortuosity and proteomic markers enhances its potential as a recurrence biomarker.