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Published on: August 12, 2019
Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides
Kaili Miao1, Jin Zhang1, Jiaxin Chen1
1College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao, 266042, China.
Abstract:
The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules. Mechanistic studies indicate that an enamide intermediate might be involved.
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