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Structural plasticity of the coiled-coil interactions in human SFPQ

Heidar J Koning1, Jia Y Lai1, Andrew C Marshall1

  • 1School of Molecular Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.

Nucleic Acids Research
|December 19, 2024
PubMed
Summary

SFPQ and NONO proteins form polymers through coiled-coil interactions, influencing paraspeckle assembly and cellular functions. This study reveals novel coiled-coil interfaces critical for DBHS protein polymerization and disease association.

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