Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

21.7K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.7K
The Replisome03:01

The Replisome

33.0K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
33.0K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

17.6K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
17.6K
DNA Packaging00:58

DNA Packaging

102.0K
Overview
102.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinspired reconfigurable cloverleaf DNA origami as a versatile platform for visual molecular detection.

RSC advances·2025
Same author

Multitask Level-Based Learning Swarm Optimizer.

Biomimetics (Basel, Switzerland)·2024
Same author

Adaptive Bi-Operator Evolution for Multitasking Optimization Problems.

Biomimetics (Basel, Switzerland)·2024
Same author

Scalable DNA recognition circuits based on DNA strand displacement.

Nanoscale advances·2024
Same author

Massively Parallel DNA Computing Based on Domino DNA Strand Displacement Logic Gates.

ACS synthetic biology·2022
Same author

Using amino acid features to identify the pathogenicity of influenza B virus.

Infectious diseases of poverty·2022
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.2K

Instruction-responsive programmable assemblies with DNA origami block pieces.

Fang Wang1, Xiaolong Shi2,3, Xin Chen4

  • 1School of Computer Science and Cyber Engineering, GuangZhou University, 230 Wai Huan Xi Road, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.

Nucleic Acids Research
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed DNA origami building block pieces (DOBPs) for programmable finite arrays. This DNA nanotechnology innovation enables controlled self-assembly of diverse nanostructures and molecular information processing.

More Related Videos

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.0K

Related Experiment Videos

Last Updated: Jun 4, 2025

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.2K
Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

14.5K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.0K

Area of Science:

  • DNA nanotechnology
  • Nanofabrication
  • Molecular computing

Background:

  • DNA nanotechnology offers platforms for nanofabrication and DNA computing.
  • Current limitations exist in constructing programmable finite arrays for easy pre-functionalization.

Purpose of the Study:

  • To develop standardized and controllable DNA origami components for assembling diverse superstructures.
  • To enable finite-scale assembly driven by instruction sets.

Main Methods:

  • Design and implementation of DNA origami building block pieces (DOBPs) with eight independent programmable edges.
  • Formulation of DNA instructions for tailored component assembly.
  • Experimental validation of assembly strategies and connection methods.

Main Results:

  • DOBPs can be assembled into specific 2D arrays based on instruction sets, with a two-unit system theoretically generating 48 distinct arrays.
  • Demonstrated both deterministic and nondeterministic assembly capabilities of DOBPs.
  • Successfully assembled complex 2D arrays ('square frames', 'windmills', 'long strips') and implemented Boolean logic gates ('AND', 'XOR').

Conclusions:

  • The DOBP system provides a model nanostructure for controllable finite self-assembly research.
  • Offers an integrated approach for molecular information storage and processing.
  • Advances the field of programmable DNA-based nanostructures.