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Updated: Jun 4, 2025
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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
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Evaluation Of Maternal And Fetal Findings In Patients With Pemphigoid Gestationis
Nihan Erdoğan Atalay1, Funda Dağıstanlı2, Hayal Uzelli Şimşek3
1Department of Obstetrics and Gynecology, Bolu Izzet Baysal State Hospital, Bolu, Turkey.
Summary
Pemphigoid gestationis in pregnant women poses significant risks for severe maternal morbidity and adverse fetal outcomes. Early diagnosis and multidisciplinary monitoring are crucial for high-risk pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Dermatology
- Neonatology
Background:
- Pemphigoid gestationis (PG) is a rare, autoimmune subepidermal blistering disease specific to pregnancy.
- It can lead to significant maternal and fetal complications.
Purpose of the Study:
- To evaluate maternal and fetal outcomes in 12 pregnant women diagnosed with pemphigoid gestationis.
- To review existing literature on the condition.
Main Methods:
- Retrospective review of medical records for 12 PG patients.
- Data collected between January 2014 and January 2024.
Main Results:
- Mean maternal age 30 years, delivery at 33 weeks, birth weight 2146g.
- Adverse outcomes included intrauterine growth restriction (4 patients), oligohydramnios (2), hypertension (1), placental abruption (1), and gestational diabetes mellitus (1).
- Six neonates required NICU admission; one mother required ICU admission.
Conclusions:
- Pemphigoid gestationis is associated with substantial maternal morbidity and adverse fetal outcomes.
- Early diagnosis of lesions and high-risk pregnancy monitoring via a multidisciplinary approach are recommended.
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