Proteomics for Biomarker Discovery in Gynecological Cancers: A Systematic Review

Dong-Hui Huang ^1,2,3, Yi-Zi Li ^1,2,3, He-Li Xu ^1,2,3

⁰Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Journal of Proteome Research +

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December 19, 2024

View abstract on PubMed

Summary

This study identifies key biomarkers consistently found in gynecological cancers (GCs). These include collagens, fibrinogens, chaperones, and apolipoproteins, crucial for cancer development and function.

Area Of Science

Oncology
Biochemistry
Bioinformatics

Background

Gynecological cancers (GCs) present a significant global health challenge.
Identifying reliable biomarkers is crucial for early detection and targeted therapy in GCs.
Current proteomic research offers potential candidates but requires comprehensive summarization and analysis.

Purpose Of The Study

To systematically review and analyze the proteomic biomarker landscape in cervical, endometrial, and ovarian cancers.
To integrate bioinformatics analysis to identify consistently regulated biomarkers and their associated biological processes.
To provide a consolidated view of potential biomarkers for GCs.

Main Methods

Systematic literature search across major scientific databases (PubMed, Web of Science, Embase, Scopus, Ovid Medline, Cochrane Library) up to December 7, 2022.
Inclusion of 23 articles focusing on proteomic research for cervical, endometrial, and ovarian cancers.
Bioinformatics analysis using the PANTHER classification system and STRING database for protein-protein interaction networks.

Main Results

Identification of consistently regulated candidate biomarkers (CBs) across GCs, including collagens (alpha-2(I), alpha-1(III), alpha-2(V) chains), calreticulin, protein disulfide-isomerase A3, heat shock protein family A (Hsp70) member 5, prolyl 4-hydroxylase beta polypeptide, fibrinogen (alpha and gamma chains), and apolipoproteins (B-100, C-IV, M).
Bioinformatics analysis revealed these CBs are involved in critical cellular functions such as collagen fibril organization, blood coagulation, protein folding in the endoplasmic reticulum, and lipid transport.
Collagens, fibrinogens, chaperones, and apolipoproteins emerged as consistently replicated and regulated protein families in GCs.

Conclusions

Collagens, fibrinogens, chaperones, and apolipoproteins represent a core group of consistently regulated biomarkers in gynecological cancers.
These identified biomarkers play significant roles in the etiology and physiology of GCs.
The findings highlight potential targets for future diagnostic and therapeutic strategies in gynecological oncology.

Keywords:

biomarker cervical cancer endometrial cancer gynecological cancers ovarian cancer proteomics

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