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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Multiomics Approach Identifies Key Proteins and Regulatory Pathways in Colorectal Cancer.

Jun Rao1, Xing Wang2, Xianghui Wan1

  • 1The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Institute, Jiangxi Cancer Hospital, Nanchang 330029, Jiangxi Province, China.

Journal of Proteome Research
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

Researchers identified vesicle-associated membrane protein-associated protein A (VAPA) as a potential biomarker for colorectal cancer (CRC). Decreased VAPA levels correlate with CRC progression and poorer survival, highlighting its diagnostic and prognostic potential.

Keywords:
VAPAcholesterol metabolismcolorectal cancermetabolomicsproteomics

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Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) incidence is rising, yet effective early diagnostic biomarkers are scarce.
  • There is a critical need for molecular insights into CRC development and progression.

Purpose of the Study:

  • To comprehensively characterize the molecular landscape of colorectal cancer using a multiomics approach.
  • To identify novel biomarkers for early diagnosis and therapeutic targeting in CRC.

Main Methods:

  • Employed a multiomics strategy, including proteomics and metabolomics, on eight distinct CRC sample types.
  • Analyzed protein expression differences in tumor tissues, plasma, and white blood cells from CRC patients and controls.
  • Investigated metabolic pathway enrichment associated with identified molecular changes.

Main Results:

  • Identified significant protein expression changes in CRC tissues, plasma, and white blood cells.
  • Discovered vesicle-associated membrane protein-associated protein A (VAPA) is consistently downregulated in CRC and linked to patient survival.
  • Validated 37 enriched pathways in CRC, with VAPA-related pathways including PI3K-Akt signaling and metabolism also present in precancerous lesions.

Conclusions:

  • Vesicle-associated membrane protein-associated protein A (VAPA) shows promise as a key regulator and potential biomarker for colorectal cancer.
  • VAPA and its associated signaling/metabolic pathways may serve as targets for early CRC diagnosis and prognosis.