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Parameter map guided explainable segmentation framework for breast cancer using amide proton transfer weighted

Qiuhui Yang1,2, Meng Wang3, Weiqiang Dou4

  • 1Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.

Medical Physics
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel multi-task network for segmenting breast lesions in Amide Proton Transfer (APT) imaging. The model leverages varying contrasts in APTw images, improving accuracy and aiding diagnosis.

Keywords:
MRIamide proton transfer weighted imagingbreast cancerexplainable framework

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Oncology

Background:

  • Amide proton transfer weighted (APTw) imaging is crucial for breast cancer diagnosis, treatment evaluation, and prognosis.
  • Automatic segmentation of breast lesions in APTw images is challenging but necessary for quantification.

Purpose of the Study:

  • To develop a segmentation model for APTw imaging using original images.
  • To utilize varying contrasts between lesions and surrounding tissues at different frequency offsets for improved segmentation.

Main Methods:

  • A multi-task network was proposed, integrating lesion segmentation, pathological classification, and APTw parameter map fitting.
  • The segmentation model incorporates multiple images at different frequencies to leverage varying tissue contrasts.

Main Results:

  • The proposed method achieved higher accuracy (ACC) compared to advanced models like U-Net, SAM, Med-SAM, and TransBTS.
  • Model interpretability was enhanced, showing how varying gray contrasts contribute to segmentation.
  • Pathological classification and parametric map fitting tasks were shown to improve segmentation accuracy.

Conclusions:

  • Multi-task learning, specifically pathological classification and parameter fitting, can enhance breast lesion segmentation accuracy in APTw imaging.
  • The developed model offers a promising approach for automated breast lesion segmentation in clinical settings.