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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Thyroid hormone and the Liver
Lorraine Soares De Oliveira1, Megan J Ritter
1Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Hepatology Communications
|December 19, 2024
Summary
Thyroid hormone (TH) impacts liver metabolism, and its receptor THRβ is key. This review explores TH
Area of Science:
- Hepatology
- Endocrinology
- Metabolic Diseases
Background:
- Thyroid hormone regulates key hepatic metabolic pathways, including cholesterol metabolism, lipogenesis, and fatty acid oxidation.
- Thyroid hormone receptor beta (THRβ) is the primary isoform in the liver, mediating thyroid hormone action.
- Hypothyroidism is linked to dyslipidemia and metabolic dysfunction-associated fatty liver disease (MAFLD).
Purpose of the Study:
- To explore the intricate relationship between thyroid hormone, liver function, and MAFLD.
- To review current therapeutic strategies for MAFLD involving thyroid hormone analogs.
- To identify future research directions in thyroid hormone-based MAFLD treatments.
Main Methods:
- Literature review of existing studies on thyroid hormone and liver metabolism.
- Analysis of clinical data regarding thyroid hormone dysregulation and MAFLD.
- Examination of the role of thyroid hormone receptor (THR) isoforms and coregulators.
Main Results:
- Thyroid hormone plays a crucial role in maintaining hepatic metabolic homeostasis.
- Thyroid hormone analogs, such as resmetirom, show promise in treating MAFLD.
- Dysregulation of thyroid hormone contributes to the pathogenesis of MAFLD and associated dyslipidemias.
Conclusions:
- Thyroid hormone is a critical regulator of liver metabolism and a potential therapeutic target for MAFLD.
- Thyroid hormone analogs represent a novel therapeutic avenue for managing MAFLD.
- Further research is needed to fully elucidate the therapeutic potential of targeting the thyroid hormone pathway in liver disease.
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