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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Analysis of omission of antimicrobial doses in Intensive Care Units

Isabelle Ribeiro Machado1, Danielle de Mendonça Henrique1, Flávia Giron Camerini1

  • 1Universidade do Estado do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

Revista Brasileira De Enfermagem
|December 19, 2024
PubMed
Abstract

Insights

In intensive care units, 4.29% of antimicrobial doses were omitted. Double-checking prescriptions significantly reduced these omissions, improving patient safety and antimicrobial stewardship.

Area of Science:

  • Clinical Pharmacy
  • Infectious Diseases
  • Patient Safety

Background:

  • Antimicrobial dose omission is a critical issue in healthcare settings.
  • Preventing medication errors is essential for effective treatment and combating antimicrobial resistance.

Purpose of the Study:

  • To determine the frequency of antimicrobial dose omission in intensive care units (ICUs).
  • To identify factors associated with antimicrobial dose omission.
  • To evaluate the impact of prescription review on dose omission rates.

Main Methods:

  • A cross-sectional study was conducted in ICUs of a University Hospital in Rio de Janeiro from March 1 to September 30, 2023.
  • Analysis included 452 prescriptions and 1467 antimicrobial doses.
  • Statistical methods were used to assess the dose omission rate and influencing factors.

Main Results:

  • The overall antimicrobial dose omission rate was 4.29%.
  • Each additional antimicrobial prescription increased the likelihood of dose omission by 51%.
  • Implementing a double-checking strategy for prescriptions prevented 30% of antimicrobial dose omissions (p=0.0001).

Conclusions:

  • Regular monitoring of antimicrobial dose omission is crucial for enhancing nursing practices and patient safety.
  • Reducing dose omissions contributes to preventing medication errors and supports antimicrobial stewardship programs.
  • These findings aid in the global effort to combat antimicrobial resistance.

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