PROGNOSTIC MARKERS FOR THROMBOTIC EVENTS IN PATIENTS WITH GASTRIC OR COLORECTAL ADENOCARCINOMAS
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated thrombin-antithrombin complex levels predict thrombosis risk in gastric and colorectal cancer patients. Prophylactic anticoagulation is recommended for patients with low Karnofsky Performance Status or high thrombin-antithrombin complex levels.
Area Of Science
- Oncology
- Hematology
- Biochemistry
Background
- Cancer establishes a prothrombotic state in patients.
- Blood coagulation activation is linked to tumor progression and metastasis.
Purpose Of The Study
- To determine if plasma circulation tumor DNA and thrombin-antithrombin complex levels predict thrombotic events and death in gastric/colorectal cancer patients.
- To evaluate the predictive value of Karnofsky Performance Status for these outcomes.
Main Methods
- Eighty-two patients were studied (20 controls, 21 gastric adenocarcinoma, 41 colorectal adenocarcinoma).
- Karnofsky Performance Status was assessed via daily task performance.
- Serum markers including thrombin-antithrombin complex and extracellular DNA were measured.
Main Results
- 16% of patients experienced thrombosis.
- Thrombin-antithrombin complex levels >0.53 indicated a fivefold increased thrombosis risk.
- Lower Karnofsky Performance Status was a risk factor for thrombosis.
- Neither marker predicted death; Karnofsky index predicted better survival.
Conclusions
- Thrombin-antithrombin complex is a thrombosis marker in gastric and colorectal adenocarcinomas.
- Prophylactic anticoagulation is advised for low Karnofsky values or thrombin-antithrombin complex >0.53 ng/ml.
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