Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of an educational podcast on emotional wellbeing and attitudes towards Charles Bonnet syndrome hallucinations.

Therapeutic advances in ophthalmology·2026
Same author

Women in vision networks: narrowing the global gender gap in academia.

Therapeutic advances in ophthalmology·2026
Same author

Feasibility of smartphone-based digital phenotyping to measure visual function and mental health outcomes in patients with inherited retinal diseases.

NPJ digital medicine·2026
Same author

Visual acuities in patients with autosomal recessive retinitis pigmentosa associated with four rod phototransduction genes.

Eye (London, England)·2026
Same author

Synonymous editing alters ion channel function, favoring prime editing for retinal disease correction.

International journal of biological sciences·2026
Same author

Whole-genome sequencing uncovers diverse genetic causes and phenotypic signatures in infantile nystagmus and albinism.

NPJ genomic medicine·2026
Same journal

Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.

Translational vision science & technology·2026
Same journal

Optical Quality and Centration Stability of a Novel Capsule Reconstructor for Intraocular Lens Fixation: Laboratory Evaluation of the fixOflex Device.

Translational vision science & technology·2026
Same journal

The Role of Nrf2 in SIRT1-Mediated RGC Neuroprotection in Traumatic Optic Neuropathy.

Translational vision science & technology·2026
Same journal

Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.

Translational vision science & technology·2026
Same journal

Preclinical Safety and Feasibility Study of Line-Field Confocal Optical Coherence Tomography for Ophthalmology Applications.

Translational vision science & technology·2026
Same journal

Pathogenicity Analysis of Two Novel CRB1 Mutations in Three Chinese Inherited Retinal Dystrophy Families and a Literature Review.

Translational vision science & technology·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

A Method to Quantify Visual Information Processing in Children Using Eye Tracking
09:47

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

Published on: July 9, 2016

17.4K

Assessing Contrast Sensitivity Function in CRB1-Retinopathies: Exploring Child-Friendly Measures of Visual Function.

Ana Catalina Rodriguez-Martinez1,2,3, Vijay K Tailor-Hamblin1,2,4, Michael D Crossland1

  • 1UCL Institute of Ophthalmology, London, UK.

Translational Vision Science & Technology
|December 19, 2024
PubMed
Summary
This summary is machine-generated.

Contrast sensitivity function (CSF) is a promising trial endpoint for CRB1-retinopathies. Patients with CRB1 gene mutations showed significantly reduced CSF, with early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) phenotypes exhibiting the lowest levels.

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.6K
Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System
05:10

Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System

Published on: March 17, 2023

2.6K

Related Experiment Videos

Last Updated: Jun 4, 2025

A Method to Quantify Visual Information Processing in Children Using Eye Tracking
09:47

A Method to Quantify Visual Information Processing in Children Using Eye Tracking

Published on: July 9, 2016

17.4K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.6K
Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System
05:10

Author Spotlight: An Automated Method for Assessing Visual Acuity in Infants and Toddlers Using an Eye-Tracking System

Published on: March 17, 2023

2.6K

Area of Science:

  • Ophthalmology
  • Genetics
  • Vision Science

Background:

  • CRB1 gene mutations cause various retinal dystrophies, including EOSRD/LCA, CORD, and MD.
  • Developing reliable outcome measures is crucial for advancing CRB1-retinopathy treatments.

Purpose of the Study:

  • To evaluate the contrast sensitivity function (CSF) across spatial frequencies in CRB1-retinopathy patients.
  • To assess the utility of the child-friendly PopCSF test as a functional vision assessment tool.

Main Methods:

  • A prospective cross-sectional study of 20 patients with confirmed CRB1 pathogenic variants.
  • Measurements included best-corrected visual acuity (BCVA), Pelli-Robson contrast sensitivity, and the PopCSF test.
  • Comparison of CSF across different CRB1 phenotypes and with controls.

Main Results:

  • No significant difference in BCVA between phenotypes (P=0.066).
  • Significant differences in log contrast sensitivity (P=0.047) and area under the CSF (P<0.001) between groups.
  • CRB1 patients demonstrated reduced CSF at low and high spatial frequencies compared to controls; EOSRD/LCA patients had the lowest CSF.

Conclusions:

  • The PopCSF test effectively measured CSF differences in CRB1-retinopathy patients.
  • CSF is a sensitive outcome measure for CRB1-retinopathies, particularly for differentiating phenotypes.
  • CSF shows potential as a functional vision trial endpoint for CRB1-related retinal diseases.