Significant association between three atherosclerosis indexes and stroke risk

Area of Science:

• Cardiovascular epidemiology
• Geriatric medicine
• Biomarkers of atherosclerosis

Background:

• Atherosclerosis is a major risk factor for stroke, particularly in older populations.
• Identifying reliable predictors of stroke is crucial for preventative strategies in elderly individuals.

Purpose of the Study:

• To investigate the association between three atherosclerosis indexes and the risk of stroke.
• To evaluate the predictive value of the atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), and Castelli risk index II (CRI-II) for stroke in adults aged 65 and older.

Main Methods:

• Utilized data from the China Health and Retirement Longitudinal Study (2011-2015).
• Employed multivariate logistic regression models and restricted cubic splines to analyze stroke risk.
• Assessed associations across quartiles and as continuous variables for the three indexes.

Main Results:

• Higher quartiles of AIP, CRI-I, and CRI-II were associated with increased stroke risk (ORs ranging from 1.35 to 1.52).
• Per-unit increases in AIP, CRI-I, and CRI-II were independently linked to higher stroke risk (ORs: 1.49, 1.06, and 1.14, respectively).
• Significant associations were observed after multivariate adjustments.

Conclusions:

• The atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), and Castelli risk index II (CRI-II) are significant predictors of stroke.
• These atherosclerosis indexes may aid in identifying elderly individuals at higher risk for stroke in the Chinese population.