International trends in biliary tract cancer-related mortality, 2000-2022: An observational study of the World Health Organization Mortality Database
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Biliary tract cancer mortality remained stable internationally, but intrahepatic cholangiocarcinoma (iCCA) rates significantly increased. This highlights the need for targeted screening and management strategies for iCCA.
Area Of Science
- Oncology
- Epidemiology
- Public Health
Background
- Biliary tract cancers (BTCs), encompassing intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary cancer, are associated with poor prognoses.
- Understanding temporal mortality trends is crucial for public health interventions.
Purpose Of The Study
- To examine international, regional, and national temporal trends in mortality due to BTCs and their major subtypes.
- To identify disparities in mortality rates and trends across different geographical areas and over time.
Main Methods
- Utilized the World Health Organization mortality database for an observational study.
- Employed Locally Weighted Regression (LOESS) for smoothed long-term mortality rate analysis (2000-2022).
- Applied joinpoint regression analysis to examine age-standardized mortality rate (ASR) trends in individual countries (2013-2022).
Main Results
- Internationally, BTC-associated ASRs showed a stable trend, decreasing slightly from 2.8/100,000 in 2000 to 2.7/100,000 in 2022.
- The Western Pacific region exhibited the highest BTC-related ASRs (4.2/100,000) in 2022.
- Significant subtype-specific trends were observed: iCCA ASRs increased by 120.0%, gallbladder cancer ASRs decreased by 45.5%, and extrahepatic cholangiocarcinoma ASRs remained stable.
- Increasing iCCA-associated ASR trends were noted in numerous countries between 2013-2022.
Conclusions
- Despite stable overall BTC mortality, the substantial rise in iCCA-associated ASRs is a significant public health concern.
- Effective screening programs for high-risk populations and improved disease management strategies are urgently needed for iCCA.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...