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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Cytotoxic T Cells-mediated Immune Response01:27

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The complement system in clinical oncology: Applications, limitations and challenges.

Daniel Ajona1, Mark S Cragg2, Ruben Pio1

  • 1Laboratory of Translational Oncology, Program in Solid Tumors, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain; Department of Biochemistry and Genetics, School of Sciences, Universidad de Navarra, Pamplona, Spain; Navarra's Health Research Institute (IDISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.

Seminars in Immunology
|December 19, 2024
PubMed
Summary

The complement system plays a dual role in cancer, impacting tumor growth and therapy effectiveness. Understanding its complex functions is key to developing novel cancer treatments and biomarkers.

Keywords:
BiomarkersCancerClinical trialsComplement systemTherapy

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Area of Science:

  • Immunology
  • Oncology

Background:

  • The complement system, part of innate immunity, has a complex role in cancer.
  • It can both inhibit tumor progression and promote a tumor-supportive microenvironment.

Purpose of the Study:

  • To review recent advances in understanding complement's role in cancer.
  • To explore how these insights are being translated into clinical applications.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of therapeutic agents targeting the complement system.
  • Examination of combination therapies involving complement modulation.

Main Results:

  • The complement system exhibits dual functions in cancer, influencing tumor progression and therapeutic responses.
  • Therapeutic strategies modulating complement are emerging, including novel agents and combination therapies.

Conclusions:

  • Understanding the complement system's role in cancer is crucial for developing new therapeutic strategies.
  • This field holds potential for novel cancer treatments and clinically relevant biomarkers.