Fibrinolytic uses in the emergency department: a narrative review

Several life-threatening conditions associated with thrombosis include acute ischemic stroke (AIS), acute myocardial infarction (AMI), and acute pulmonary embolism (PE). Fibrinolytics are among the treatment algorithms for these conditions.

This narrative review provides emergency clinicians with an overview of fibrinolytics for AIS, AMI, and PE in the emergency department (ED) setting.

Pathologic thrombosis can result in vascular occlusion and embolism, ultimately leading to end-organ injury. Fibrinolytics are medications utilized to lyse a blood clot, improving vascular flow. One of the first agents utilized was streptokinase, though this is not as often used with the availability of fibrin-specific agents including alteplase (tPA), tenecteplase (TNK), and reteplase (rPA). These agents are integral components in the management of several conditions, including AIS, AMI, and PE. Patients with AIS who present within 3-4.5 h of measurable neurologic deficit with no evidence of intracerebral hemorrhage (ICH) or other contraindications may be eligible to receive tPA or TNK. In the absence of percutaneous coronary intervention (PCI), fibrinolytics should be considered in patients with AMI presenting with chest pain for at least 30 min but less than 12 h, though it may be considered up to 24 h. Unlike in AIS and PE, anticoagulation and antiplatelet medications should be administered in those with AMI receiving fibrinolytics. Following fibrinolytics, PCI is typically necessary. Fibrinolytics are recommended in patients with high-risk PE (hemodynamic instability), as they reduce the risk of mortality. The most significant complication following fibrinolytic administration includes major bleeding such as ICH, which occurs most frequently in those with AIS compared to AMI and PE. Thus, close patient monitoring is necessary following fibrinolytic administration.

An understanding of fibrinolytics in the ED setting is essential, including the indications, contraindications, and dosing.