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Maternal death associated with sickle cell trait.

J G Pastorek, B Seiler

    American Journal of Obstetrics and Gynecology
    |February 1, 1985
    PubMed
    Summary
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    A patient with sickle cell trait experienced sudden death during childbirth, likely due to peripartal cardiomyopathy exacerbated by intravascular sickling. Autopsy revealed widespread sicklemia affecting all organs.

    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Cardiology

    Background:

    • Sickle cell trait is a common hemoglobinopathy.
    • Peripartal cardiomyopathy is a rare form of heart failure.
    • Intrapartum complications require careful management.

    Observation:

    • A case report details an abrupt intrapartum death in a patient with sickle cell trait.
    • The death was likely precipitated by peripartal cardiomyopathy.
    • Intravascular sickling appeared to aggravate the condition.

    Findings:

    • Massive sicklemia was observed in all organ systems during autopsy.
    • The patient had sickle cell trait.
    • The autopsy findings correlate with the clinical presentation.

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    Implications:

    • This case highlights the potential risks of sickle cell trait in pregnancy.
    • It underscores the importance of considering cardiac complications in pregnant patients with sickle cell trait.
    • Early recognition and management of peripartal cardiomyopathy are crucial in high-risk pregnancies.