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siRNA-based therapy for overcoming drug resistance in human solid tumours; molecular and immunological approaches

Harikumar Pallathadka1, Majid Jabir2, Khetam Habeeb Rasool3

  • 1Manipur International University, Imphal, Manipur, India.

Human Immunology
|December 19, 2024
PubMed

Insights

Small interfering RNA (siRNA) therapy shows promise in overcoming cancer drug resistance by silencing specific genes. This approach can re-sensitize cancer cells to chemotherapy, advancing personalized cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • RNA interference (RNAi) is a natural defense mechanism.
  • Small interfering RNA (siRNA) offers sequence-specific gene silencing for therapeutic potential.
  • siRNA therapies are increasingly recognized for their efficacy in cancer treatment.

Purpose of the Study:

  • To review the role of siRNA in overcoming cancer drug resistance.
  • To explore how siRNA can re-sensitize cancer cells to chemotherapy.
  • To identify key genes involved in cancer cell characteristics and drug resistance for targeted siRNA development.

Main Methods:

  • Non-systematic review of relevant literature.
  • Sources selected from PubMed, Scopus, and Google Scholar using pertinent keywords.
  • Focus on in vitro studies published from 2020 onwards.

Main Results:

  • siRNA can effectively suppress cancer cell growth and proliferation.
  • siRNA therapies enhance sensitivity to chemotherapy by targeting drug resistance genes.
  • Silencing genes involved in drug efflux, cell survival, and DNA repair restores medication efficacy.

Conclusions:

  • siRNA holds significant potential for addressing drug resistance in human tumors.
  • Targeted gene silencing with siRNA opens new avenues for personalized cancer therapy.
  • Further research into barriers and future perspectives of siRNA therapies is warranted.
Keywords:
CancerDrug resistanceMolecular immunologysiRNA

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