Give me a sign(ature): Converging on the CSC of glioblastoma
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Updated: Jul 23, 2026

Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry
Published on: January 7, 2014
Kunal S Patel1, Lindsey Dudley2, Harley I Kornblum2
1Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA.
Abstract:
The identification of stem cells in glioblastomas has been controversial. In this issue of Neuron, Xie et al.1 establish gene signatures for cellular states and a quiescent cancer stem cell (qCSC) and demonstrate that the qCSC population expands in recurrence.
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