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Updated: Jun 4, 2025
08:48
Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
Published on: December 21, 2016
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Research Progress on the Correlation Between Atmospheric Particulate Matter and Autism.
Yaqian Xiao1,2,3, Wang Xiang1,2,3, Xuerui Ma1,2,3
1Cooperative Innovation Center of Industrial Fermentation, Ministry of Education & Hubei Province, Hubei University of Technology, Wuhan, Hubei, China.
Journal of Applied Toxicology : JAT
|December 19, 2024
Summary
Air pollution, specifically fine particulate matter (PM2.5) and inhalable particulate matter (PM10), is increasingly linked to autism spectrum disorder (ASD) risk. This review explores the mechanisms, including neuroinflammation and synaptic injury, connecting PM exposure to ASD pathogenesis.
Area of Science:
- Environmental Health
- Neuroscience
- Genetics
Background:
- Autism spectrum disorder (ASD) prevalence is rising globally, particularly in industrialized areas.
- Environmental factors, alongside genetics, are implicated in ASD development.
- Particulate matter (PM) air pollution is a suspected environmental contributor to ASD.
Purpose of the Study:
- To review epidemiological studies correlating PM2.5 and PM10 with ASD.
- To elucidate the pathogenic mechanisms of PM exposure in ASD.
- To examine the role of the ASD candidate gene SHANK3 in PM-induced neurotoxicity.
Main Methods:
- Literature search and analysis of epidemiological studies.
- Review of signaling pathways and pathogenic mechanisms of PM on synaptic injury and neuroinflammation.
- Analysis of PM effects in animal models and human studies.
Main Results:
- PM exposure is associated with increased ASD risk.
- PM induces neuroinflammation and synaptic injury, contributing to ASD pathogenesis.
- Different PM types exhibit distinct sites of action and effects on ASD development.
Conclusions:
- PM air pollution is a significant environmental risk factor for ASD.
- Understanding PM-induced neurotoxic mechanisms is crucial for ASD prevention and intervention.
- Further research is needed to refine assessment methods and explore technological innovations.
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