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Global collaboration between platform trials in surgery and anaesthesia.
James Glasbey1, Steve A Webb2,3, Trisha Peel4,5
1Academic Department of Surgery, University of Birmingham, Birmingham, UK.
The British Journal of Surgery
|December 19, 2024
Summary
Adaptive platform trials accelerate the identification of effective or harmful treatments, overcoming resource limitations of traditional randomized trials. These innovative methods offer rapid evidence generation for clinical questions, particularly in surgery and anesthesia.
Area of Science:
- Clinical Trials
- Evidence-Based Medicine
- Surgical Research
Background:
- Large, randomized trials are essential for evidence-based medicine but are resource-intensive, limiting the scope of clinical questions addressed.
- Traditional trial designs face challenges in timely evidence generation due to resource constraints.
Purpose of the Study:
- To highlight the advantages of adaptive platform trials in accelerating evidence generation.
- To emphasize the growing adoption and opportunities for adaptive platform trials in surgery and anesthesia.
Main Methods:
- Adaptive platform trials allow for efficient evaluation of multiple treatments within a single trial infrastructure.
- These trials dynamically adjust based on accumulating data, enabling faster identification of effective or harmful interventions.
Main Results:
- Adaptive platform trials have demonstrated success in delivering rapid evidence, notably during the COVID-19 pandemic.
- The adoption of platform trials is expanding into surgical and anesthesia fields.
Conclusions:
- Adaptive platform trials offer a faster and more resource-efficient approach to answering critical clinical questions compared to traditional trials.
- Perioperative physicians, including surgeons and anesthesiologists, are encouraged to engage in and collaborate on platform trials to advance clinical practice.
