[Historical evolution and modern research on co-production and processing method of "solid-liquid excipients"]

Area of Science:

• Pharmacology
• Traditional Chinese Medicine Processing
• Material Science

Background:

• Solid-liquid excipient co-production is a long-standing technique in Traditional Chinese Medicine (TCM).
• This method is crucial for reducing toxicity, moderating properties, and improving the clinical efficacy of TCM formulations.
• Despite its historical significance and benefits, modern scientific research has paid limited attention to these processing methods.

Purpose of the Study:

• To review the historical development of solid-liquid excipient co-production.
• To outline modern processing standards and methods across different TCM schools.
• To elaborate on the purposes and effects of solid-liquid excipient co-production.

Main Methods:

• Historical literature review on solid-liquid excipient co-production.
• Analysis of modern processing standards and techniques from various TCM schools.
• Elaboration on the pharmacological and clinical effects of the co-production method.

Main Results:

• The historical evolution and widespread application of solid-liquid excipient co-production were detailed.
• Current processing standards and methods used in different TCM schools were outlined.
• The study confirmed the benefits of reducing toxicity and enhancing efficacy through this method.

Conclusions:

• Solid-liquid excipient co-production offers significant advantages in TCM processing, including reduced toxicity and improved efficacy.
• There is a need for increased modern scientific investigation into these traditional methods.
• This review provides a foundation for future research, innovation, and practical application of solid-liquid excipient co-production.