[One new galloyl derivative from Isodon henryi]

Area of Science:

• Natural Product Chemistry
• Pharmacognosy
• Medicinal Chemistry

Context:

• Isodon henryi is a plant source of bioactive compounds.
• Phytochemical investigations aim to discover novel therapeutic agents.
• Nitric oxide (NO) plays a crucial role in inflammatory processes.

Purpose:

• To isolate and characterize chemical constituents from Isodon henryi.
• To identify novel compounds with potential pharmacological activities.
• To evaluate the inhibitory effect of isolated compounds on nitric oxide production.

Summary:

• Seven compounds, including isogallicacid (1), caffeic acid (2), syringic acid (3), protocatechuic acid (4), oresbiusin A (5), lophanthoside A (6), and 8-hydroxypinoresinol (7), were isolated from Isodon henryi.
• Compound 1, a new galloyl derivative, was identified using advanced spectroscopic techniques (HR-MS, IR, UV, NMR, ECD).
• Compound 1 demonstrated significant inhibition of nitric oxide release from RAW264.7 cells stimulated with lipopolysaccharide.

Impact:

• Discovery of a new galloyl derivative from Isodon henryi.
• Identification of potential anti-inflammatory properties of natural products.
• Provides a basis for further research into the therapeutic applications of Isodon henryi constituents.