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Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a
Zihan Chen1, Yuxiong Chen2,3, Yuanmeng Li1
1Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
BMC Musculoskeletal Disorders
|December 20, 2024
Summary
Impaired thyroid hormone sensitivity is linked to poorer bone microarchitecture in euthyroid individuals. This finding highlights a potential connection between thyroid function and bone health.
Area of Science:
- Endocrinology
- Bone Metabolism
- Public Health
Background:
- Thyroid hormone significantly influences bone metabolism.
- The relationship between thyroid hormone sensitivity and bone microarchitecture, assessed by trabecular bone score (TBS), is not well understood.
- This study investigates this association in euthyroid individuals.
Purpose of the Study:
- To examine the association between thyroid hormone sensitivity and bone microarchitecture (TBS) in euthyroid individuals.
- To identify potential indicators of impaired thyroid hormone sensitivity related to bone health.
Main Methods:
- Cross-sectional analysis of 3320 euthyroid participants from the NHANES 2007-2008 dataset.
- Calculation of thyroid hormone sensitivity indices: thyrotropin thyroxine resistance index (TT4RI), thyroid-stimulating hormone index (TSHI), thyroid feedback quantile-based index (TFQI), and parametric thyroid feedback quantile-based index (PTFQI).
- Statistical analysis adjusted for potential confounding variables.
Main Results:
- Impaired thyroid hormone sensitivity, indicated by higher values of TT4RI, TSHI, TFQI, and PTFQI, was significantly associated with degraded bone microarchitecture (TBS).
- A positive relationship was observed between these sensitivity indices and poorer bone microarchitecture.
- Findings were consistent across various subgroups including different ages, sexes, races, and those with diabetes, hypertension, or hyperuricemia.
Conclusions:
- Impaired thyroid hormone sensitivity is associated with degraded bone microarchitecture in euthyroid individuals.
- Further research is needed to confirm and elucidate this relationship.
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