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Prognostic significance of CEA reduction rate in patients with abnormally high preoperative CEA levels who underwent surgery for lung cancer

  • 0Department of Thoracic Surgery, Kochi Medical School, Kohasu, Oko-Cho, Nankoku-City, Kochi, 783-8505, Japan. masatamu@kochi-u.ac.jp.
Journal of Cardiothoracic Surgery +

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December 20, 2024

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December 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The rate of carcinoembryonic antigen (CEA) reduction after surgery is a significant prognostic indicator for non-small cell lung cancer (NSCLC) patients. A higher CEA reduction rate correlates with better overall survival, outperforming postoperative CEA levels alone.

Area Of Science

  • Oncology
  • Cancer Biomarkers
  • Surgical Oncology

Background

  • Non-small cell lung cancer (NSCLC) often presents with elevated carcinoembryonic antigen (CEA) levels.
  • The prognostic value of changes in CEA levels post-surgery in NSCLC requires further investigation.

Purpose Of The Study

  • To evaluate the prognostic significance of CEA level reduction after curative surgery in NSCLC patients.
  • To determine if CEA reduction rate is a more potent prognostic marker than absolute postoperative CEA levels.

Main Methods

  • Retrospective analysis of 68 NSCLC patients with preoperative CEA ≥ 10 ng/ml undergoing curative surgery (2012-2020).
  • Assessment of preoperative, postoperative CEA levels, and CEA reduction rate.
  • Utilized Receiver Operating Characteristic (ROC) curves for cut-off determination and Cox proportional hazards regression for multivariate analysis.

Main Results

  • An optimal cut-off for CEA reduction rate was determined to be 77.3%.
  • The CEA reduction rate demonstrated superior prognostic predictive power compared to preoperative and postoperative CEA levels.
  • Low CEA reduction rate was significantly associated with worse overall survival (OS) (p=0.002).
  • Multivariate analysis identified CEA reduction rate as an independent prognostic marker for OS (HR: 3.36, p=0.011).

Conclusions

  • Post-surgical CEA reduction rate is a valuable prognostic factor in NSCLC patients with high preoperative CEA.
  • CEA reduction rate serves as a more powerful predictor of overall survival than postoperative CEA levels.
  • Further large-scale studies are recommended to validate these findings.

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