Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway
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View abstract on PubMed
Summary
This summary is machine-generated.UCHL5 is dysregulated in many cancers and impacts patient survival and immune response. This protein shows potential as a predictive biomarker for cancer immunotherapy efficacy.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- UCHL5 is a multifunctional molecule implicated in tumor progression.
- Its role in cancer cell apoptosis and its association with diverse tumor types and the immune microenvironment require clarification.
Purpose Of The Study
- To investigate the pan-cancer expression patterns of UCHL5.
- To evaluate the association of UCHL5 with clinical characteristics, prognosis, and the tumor immune microenvironment across various cancer types.
- To explore the correlation between UCHL5 and immunotherapy efficacy.
Main Methods
- Utilized transcriptomic data from TCGA for 33 cancer types.
- Analyzed UCHL5 expression, clinical parameters, survival data (Cox and Kaplan-Meier methods), and protein expression from Human Protein Atlas.
- Assessed correlations with tumor-infiltrating immune cells, immunomodulators, MSI, TMB, and immunotherapy response in independent cohorts; conducted in vitro experiments on cervical cancer cells.
Main Results
- UCHL5 expression was altered in multiple cancer types, correlating with tumor stage and patient prognosis in several.
- UCHL5 negatively associated with immune and stromal scores and regulatory T cells in specific cancers.
- UCHL5 correlated with immunomodulators, MSI, TMB, and immunotherapy efficacy; UCHL5 knockout enhanced cervical cancer cell apoptosis.
Conclusions
- UCHL5 dysregulation is linked to prognosis, immune microenvironment, and immunotherapy response in various cancers.
- UCHL5 demonstrates potential as a predictive biomarker.
- Further research is needed to elucidate UCHL5's regulatory mechanisms in different cancers.
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