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Updated: Jun 4, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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PP2C phosphatases-terminators of suicidal thoughts

Lisa Lagorgette1,2, Daria A Bogdanova3,4, Ekaterina V Belotserkovskaya4

  • 1INSERM, UMR 1231, Laboratoire d'Excellence LipSTIC and « Equipe labellisée par la Ligue Nationale contre le Cancer », University of Burgundy, Dijon, France.

Cell Death & Disease
|December 20, 2024
PubMed

Insights

Serine-threonine protein phosphatases type 2C (PP2C) are crucial regulators of cell death, senescence, and autophagy. This review highlights their role in cell death pathways, emphasizing PPM1D (PP2Cδ) as a key example.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell death and its signaling pathways are critical in development and disease.
  • Post-translational modifications like phosphorylation and ubiquitination are key regulators.
  • Kinase roles in cell death are well-studied, but phosphatase involvement is less understood.

Purpose of the Study:

  • To review the role of serine-threonine PP2C phosphatases in cell death, senescence, and autophagy.
  • To highlight the regulatory functions of PP2Cs in cell death.
  • To identify PP2C phosphatases as potential drug targets.

Main Methods:

  • Literature review of recent research on PP2C phosphatases.
  • Focus on serine-threonine PP2C phosphatases.
  • Detailed examination of PPM1D (PP2Cδ) function in cell death.

Main Results:

  • PP2C phosphatases play a significant role in regulating cell death.
  • PPM1D (PP2Cδ) exemplifies the regulatory capacity of PP2Cs in cell death pathways.
  • Dephosphorylation by phosphatases is as vital as phosphorylation by kinases in cell death execution.

Conclusions:

  • PP2C phosphatases are important regulators of cell death checkpoints.
  • Further research into PP2C phosphatases may reveal novel therapeutic targets for diseases involving aberrant cell death.
  • Understanding PP2C function is crucial for comprehending cell death regulation.

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