Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redox-Active Tungsten Mono-Oxo Bis(dithiolene) Complex: A Fast-Rechargeable Anode for High-Capacity Lithium-Ion Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Redox-active Co(II) and Zn(II) Pincer Complexes as High-Capacity Anode Materials for Lithium-Ion Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024

Same author

ssPINE: Probabilistic Algorithm for Automated Chemical Shift Assignment of Solid-State NMR Data from Complex Protein Systems.

Membranes·2022

Same author

NMR Structure and Biophysical Characterization of Thermophilic Single-Stranded DNA Binding Protein from <i>Sulfolobus Solfataricus</i>.

International journal of molecular sciences·2022

Same author

Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.

Protein science : a publication of the Protein Society·2022

Same author

Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition.

The FEBS journal·2021

Same journal

The MassBank contributions of the mFam collaboration.

Metabolomics : Official journal of the Metabolomic Society·2026

Same journal

Characterizing the effect of short wavelengths on the floral flavonoid metabolome of medicinal cannabis using a comparative computational metabolomics workflow.

Metabolomics : Official journal of the Metabolomic Society·2026

Same journal

Serum metabolomic signatures integrating sphingosine-1-phosphate and tetrahydrocortisone improve prognostic assessment in non-ischemic cardiomyopathy.

Metabolomics : Official journal of the Metabolomic Society·2026

Same journal

Characterization of three new antiproliferative shikimic acid derivatives and known pyrrolizidine alkaloids from Senecio oleosus guided by diagnostic ions and molecular networking.

Metabolomics : Official journal of the Metabolomic Society·2026

Same journal

Urinary volatile organic compounds as potential non-invasive markers for childhood obesity.

Metabolomics : Official journal of the Metabolomic Society·2026

Same journal

Lipid reprogramming of stratified squamous epithelium by the high-risk HPV E6 and E6/E7 oncoproteins.

Metabolomics : Official journal of the Metabolomic Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

A-SIMA/A-MAP: a comprehensive toolkit for NMR-based metabolomics analysis.

Abigail Chiu¹, Mehdi Rahimi¹, Woonghee Lee²

¹Department of Chemistry, University of Colorado Denver, Denver, CO, 80204, USA.

Metabolomics : Official Journal of the Metabolomic Society

|December 20, 2024

Summary

This summary is machine-generated.

New software tools, A-SIMA and A-MAP, enhance metabolite identification and data analysis for NMR-based metabolomics research. These user-friendly programs integrate seamlessly into the POKY suite, improving research efficiency.

Keywords:

A-MAP A-SIMA MetaLib Metabolomics NMR POKY Software

More Related Videos

Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy

Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy

Published on: April 7, 2012

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Jun 4, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy

Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy

Published on: April 7, 2012

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

Area of Science:

Metabolomics
Computational Biology
NMR Spectroscopy

Background:

Metabolomics studies small molecules in biological systems, with applications in disease, drug development, and agriculture.
Growing interest in metabolomics necessitates advanced, user-friendly software for cutting-edge research.
Current research demands improved analytical capabilities and accessible tools for metabolomics data analysis.

Purpose of the Study:

Introduce A-SIMA (Advanced-Software for Interactive Metabolite Analysis) and A-MAP (A Multivariate Analysis Program).
Advance computational methodology in NMR-based metabolomics through enhanced metabolite identification and data analysis.
Provide user-friendly tools to meet the demands of modern metabolomics research.

Main Methods:

A-SIMA offers a graphical user interface for effortless metabolite identification from 1D and 2D NMR data.
A-MAP facilitates straightforward multivariate statistical analysis of metabolite data.
Both programs support Principal Component Analysis and Orthogonal Partial Least Squares-Discriminant Analysis.

Main Results:

A-SIMA and A-MAP are integrated into the POKY suite for NMR biomolecular analysis.
The POKY suite provides a fully integrated workflow for metabolite analysis, from identification to statistical modeling.
Tutorial videos and accessible online resources are available for program guidance and installation.

Conclusions:

A-SIMA and A-MAP represent promising advancements for metabolomics research.
These tools offer enhanced capabilities for metabolite analysis and statistical modeling with improved usability.
Integration into the POKY suite ensures accessibility, efficiency, and broader adoption in the scientific community.