Pure Biclonal Hairy Cell Leukemia-Apt Diagnosis with Multicolor Flow Cytometry
Shanza Adnan1, Saba Farrukh1, Arsalan Ahmed1
1Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
International Journal of Hematology-Oncology and Stem Cell Research
|December 20, 2024
Summary
This case report details an extremely rare instance of biclonal hairy cell leukemia (HCL), a unique B-cell neoplasm. Diagnosed via flow cytometry, this finding is extraordinary among lymphoid leukemias.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Hairy cell leukemia (HCL) is a rare B-cell neoplasm, accounting for approximately 2% of lymphoid leukemias.
- HCL typically affects elderly males and presents with pancytopenia, splenomegaly, and characteristic hairy cells in bone marrow.
- Biclonal HCL represents an exceptionally uncommon variant.


