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Cord Blood Platelet-Rich Plasma in Cesarean Section Wound Management

Amornrat Thanachaiviwat1, Sutham Suthaporn1, Patana Teng-Umnuay2

  • 1Department of Obstetrics and Gynaecology, Division of Obstetrics and Gynaecology, Police General Hospital, Bangkok, Thailand.

Obstetrics and Gynecology International
|December 20, 2024
PubMed

Insights

Cord blood platelet-rich plasma (CB-PRP) application improved wound healing in cesarean section patients, as evidenced by lower REEDA and Vancouver Scar Scale scores. However, CB-PRP did not significantly reduce postoperative pain.

Area of Science:

  • Obstetrics and Gynecology
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Platelet-rich plasma (PRP) is known to enhance wound healing and pain reduction.
  • Cord blood platelet-rich plasma (CB-PRP) is a potential alternative source for PRP, easily obtainable from umbilical cords.
  • Its application to cesarean section wounds is proposed to offer similar therapeutic benefits.

Purpose of the Study:

  • To investigate the efficacy of CB-PRP in improving wound healing and reducing pain in women undergoing cesarean sections.
  • To evaluate the impact of CB-PRP on postoperative wound healing using standardized scales.
  • To assess the pain-relieving effects of CB-PRP in the early postoperative period.

Main Methods:

  • A randomized controlled trial was conducted with 52 participants undergoing cesarean sections.
  • Participants were divided into an intervention group receiving CB-PRP and a control group.
  • CB-PRP was applied to the surgical wound site immediately after cesarean section.
  • Wound healing was assessed using the REEDA scale (days 1 and 3) and Vancouver Scar Scale (VSS) (8 weeks).
  • Pain was evaluated using the Visual Analog Scale (VAS) on days 1 and 3 postoperatively.

Main Results:

  • The CB-PRP group showed significantly lower REEDA scale scores on day 1 postoperation (p=0.009).
  • Significantly lower Vancouver Scar Scale (VSS) scores were observed in the CB-PRP group at 8 weeks postoperation (p < 0.001).
  • No significant difference in Visual Analog Scale (VAS) pain scores was found between the CB-PRP and control groups.

Conclusions:

  • CB-PRP application demonstrates potential in promoting wound healing following cesarean sections.
  • The study did not find evidence that CB-PRP reduces postoperative pain in this context.
  • Further research is warranted to confirm the wound healing benefits and explore potential pain-alleviating mechanisms of CB-PRP.

Keywords:
cord blood platelet-rich plasmaplatelet-rich plasmawound healing

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