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Normal nasal cytology in infancy.

G A Cohen, G A MacPherson, H E Golembesky

    Annals of Allergy
    |February 1, 1985
    PubMed
    Summary
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    Nasal cytology is now a safe and effective diagnostic tool for infants. Contrary to previous beliefs, healthy infants do not commonly exhibit nasal eosinophilia, making this method reliable.

    Area of Science:

    • Pediatric Allergy and Immunology
    • Respiratory Medicine
    • Diagnostic Cytology

    Background:

    • Nasal cytology is underutilized in infants due to prior reports of high rates of nasal eosinophilia in healthy infants.
    • This limited its diagnostic application in early life pediatrics.
    • Previous studies suggested eosinophils were common in normal infant nasal passages.

    Purpose of the Study:

    • To evaluate the safety and efficacy of a new nasal sampling technique for cytologic analysis in infants.
    • To determine the prevalence of nasal eosinophilia in healthy infants using an improved method.
    • To reassess the diagnostic utility of nasal cytology in the first year of life.

    Main Methods:

    • A flexible nasal probe was used to obtain nasal mucosal specimens from 22 healthy infants.

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  • Specimens were examined histologically.
  • Five infants with upper respiratory tract infections were also included for comparison.

    • Main Results:

    • No instances of nasal eosinophilia were detected in the 22 healthy infants.
    • The improved nasal sampling technique was found to be safe and well-tolerated.
    • No adverse effects were reported during the procedure in any infant.

    Conclusions:

    • The improved nasal sampling technique is safe and effective for infants, comparable to adults.
    • Healthy infants typically do not exhibit nasal eosinophilia, challenging previous assumptions.
    • Nasal cytology can be a valuable diagnostic tool in infants, particularly for allergic airway inflammation.