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Updated: Jun 4, 2025

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
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Emerging roles of angiopoietin‑like 4 in human tumors (Review)

Ruyi Liu1, Miaomiao Fu1, Pengxiang Chen1

  • 1Department of Radiation Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.

International Journal of Oncology
|December 20, 2024
PubMed

Insights

Angiopoietin-like 4 (ANGPTL4) is often overexpressed in cancers, promoting tumor growth and resistance. However, ANGPTL4 also shows antitumor effects, highlighting its complex role and potential as a cancer biomarker and therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Angiopoietin-like 4 (ANGPTL4) is a key regulator in angiogenesis, lipid metabolism, and inflammation.
  • ANGPTL4's role in human malignancies is increasingly recognized, with common overexpression in various cancers.

Purpose of the Study:

  • To review the biological functions of ANGPTL4 in tumors.
  • To discuss its association with patient prognosis and dual roles in cancer.
  • To explore its potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Literature review summarizing existing research on ANGPTL4 in cancer.
  • Analysis of ANGPTL4's transcriptional regulation by factors like HIF-1, PPARs, TGF-β, and lncRNAs.
  • Examination of signaling pathways including STATs, PI3K/AKT, and COX-2/PGE2.

Main Results:

  • ANGPTL4 overexpression promotes tumor growth, invasion, metastasis, angiogenesis, metabolic reprogramming, and resistance to therapy.
  • ANGPTL4 exhibits context-dependent antitumor effects, indicating complex roles in tumor biology.
  • Multiple factors and signaling pathways regulate ANGPTL4's function in cancer.

Conclusions:

  • ANGPTL4 plays a multifaceted role in cancer, acting as both a promoter and inhibitor.
  • Understanding ANGPTL4's dual functions is crucial for its clinical application.
  • ANGPTL4 represents a promising diagnostic biomarker and therapeutic target for human cancers.
Keywords:
angiopoietin‑like 4biomarkercancerdual rolesmalignancysignaling pathwaystherapeutic targettumor hallmarks

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