Air versus supplemental oxygen for resuscitation of term or late preterm infants at birth

Area of Science:

• Neonatal resuscitation
• Pediatric critical care
• Respiratory support

Background:

• Newborn resuscitation often involves supplemental oxygen.
• The optimal oxygen concentration and delivery method remain debated.
• Potential harms of excessive oxygen exposure in neonates are a concern.

Purpose of the Study:

• To compare the benefits and harms of air versus supplemental oxygen for resuscitation in term or late preterm infants.
• To evaluate the impact of oxygen concentrations, gestational age, titration to saturation, and country income on resuscitation outcomes.

Main Methods:

• This is a protocol for a Cochrane Review.
• The review will synthesize evidence from intervention studies.
• Key outcomes include mortality and long-term neurodevelopmental impairment.

Main Results:

• This section is not applicable as this is a review protocol.
• The review will analyze data on the primary outcomes of mortality and neurodevelopmental impairment.
• Secondary analyses will explore subgroup differences based on various clinical and economic factors.

Conclusions:

• This protocol outlines a systematic approach to evaluate resuscitation strategies.
• The findings will inform clinical guidelines for newborn resuscitation.
• Evidence synthesis will clarify the optimal use of air versus oxygen.