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Arthritis associated with ovine progressive pneumonia
American Journal of Veterinary Research
|January 1, 1985
Summary
Ovine progressive pneumonia (OPP) virus caused chronic arthritis in sheep joints. This study identified the OPP virus as the causative agent of progressive joint disease and associated lung inflammation in affected sheep.
Area of Science:
- Veterinary Pathology
- Virology
- Sheep Diseases
Background:
- Ovine progressive pneumonia (OPP) is a significant disease affecting sheep flocks worldwide.
- Arthritis has been anecdotally associated with OPP, but the causative link requires further investigation.
Purpose of the Study:
- To determine if the ovine progressive pneumonia (OPP) virus is the causative agent of chronic nonsuppurative arthritis in sheep.
- To characterize the pathological changes associated with OPP-induced arthritis.
Main Methods:
- Naturally and experimentally infected Border Leicester sheep were monitored for clinical signs of arthritis.
- Ovine progressive pneumonia (OPP) virus isolation from arthritic joints.
- Histopathological examination of affected joints and lungs.
Main Results:
- Chronic nonsuppurative arthritis developed in carpal and tarsal joints of sheep infected with OPP virus.
- Lesions included synovial membrane hyperplasia, necrosis, articular and subchondral bone erosion/necrosis, and fibrosis.
- OPP virus was isolated from arthritic joints; 7 of 14 sheep also had interstitial pneumonitis.
Conclusions:
- Ovine progressive pneumonia (OPP) virus is the causative agent of chronic nonsuppurative arthritis in Border Leicester sheep.
- The arthritis is a progressive condition that can occur with or without interstitial pneumonitis.