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Automated Robotic Liquid Handling Assembly of Modular DNA Devices

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Automating Blueprints for the Assembly of Colloidal Quasicrystal Clusters.

Diogo E P Pinto¹, Petr Šulc^2,3, Francesco Sciortino¹

¹Dipartimento di Fisica, Sapienza Università di Roma, P. le Aldo Moro 5, 00185 Rome, Italy.

|December 20, 2024

Summary

Researchers designed DNA origami building blocks for self-assembling into icosahedral quasicrystals. Molecular simulations confirmed successful assembly, paving the way for advanced nanotechnology and materials science applications.

Keywords:

DNA origami inverse design patchy particles quasicrystals self-assembly

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Area of Science:

Nanotechnology
Materials Science
Biophysics

Background:

Advancing beyond periodic self-assembly is a key challenge in nanotechnology.
Creating aperiodic structures like icosahedral quasicrystals at the colloidal scale remains experimentally difficult.
Prior efforts required complex human-designed components and faced limitations in controlling interactions.

Purpose of the Study:

To develop a framework for designing experimentally accessible building blocks for quasicrystalline self-assembly.
To present a novel design for icosahedral deoxyribonucleic acid (DNA) origami building blocks.
To demonstrate the feasibility of achieving quasicrystalline structures using these designs.

Main Methods:

Utilized a computational framework for designing self-assembling building blocks.
Developed icosahedral DNA origami structures as building blocks.
Employed molecular simulations to verify the self-assembly process and resulting structure.

Main Results:

Successfully designed DNA origami building blocks capable of forming quasicrystalline arrangements.
Molecular simulations confirmed the self-assembly into the target icosahedral quasicrystalline structure.
Demonstrated the potential of automated design protocols for complex material synthesis.

Conclusions:

Automated design protocols can facilitate the creation of complex quasicrystalline patterns.
The developed DNA origami building blocks offer a viable route to experimentally realize colloidal quasicrystals.
This work has significant implications for future advancements in material science and nanotechnology.