Hypoxia-guided treatment planning for lung cancer with dose painting by numbers

Tumor hypoxia significantly impacts the efficacy of radiotherapy. Recent developments in the technique of dose painting by numbers (DPBN) promise to improve the tumor control probability (TCP) in conventional radiotherapy for hypoxic cancer. The study initially combined the DPBN method with hypoxia-guided dose distribution optimization to overcome hypoxia for lung cancers and evaluated the effectiveness and appropriateness for clinical use of the DPBN plans. ¹⁸F-FMISO PET-CT scans from 13 lung cancer patients were retrospectively employed in our study to make hypoxia-guided radiotherapy. In the clinic, TCP and normal tissue complication probability (NTCP) derived from the DPBN plans in comparison to conventional intensity modulated radiation therapy (IMRT) plans were evaluated. Additionally, in order to investigate the improved clinical suitability, the robustness of DPBN plans in response to potential patient positioning errors and radiation resistance variations throughout the treatment course was assessed. The DPBN approach, employing voxelized prescription doses, led to an average increase of 24.47% in TCP, alongside a reduction of 1.83% in NTCP, compared to the conventional radiotherapy treatment plans. Regarding the robustness of the DPBN plans, it was observed that positional uncertainties were limited to 2 mm and radiosensitivity deviations were within 4%. The lung NTCP showed a 0.05% increase when the isocenter was moved by 3 mm in any direction, suggesting that the DPBN plan meets clinical acceptability criteria. Our study has shown that the DPBN technique has significant potential as an innovative approach to enhance the efficacy of radiotherapy for lung cancer with hypoxic regions.