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Furosemide absorption altered in decompensated congestive heart failure
Annals of Internal Medicine
|March 1, 1985
Summary
Patients with decompensated congestive heart failure show altered oral furosemide absorption. Compensated patients experienced faster drug absorption and higher peak concentrations, indicating changes in drug bioavailability during heart failure.
Area of Science:
- Pharmacology
- Cardiology
- Gastroenterology
Background:
- Congestive heart failure (CHF) can impact drug absorption.
- Oral furosemide is a common treatment for fluid overload in CHF.
Purpose of the Study:
- To investigate if oral furosemide absorption is altered in patients with decompensated congestive heart failure.
- To compare pharmacokinetic and pharmacodynamic responses between decompensated and compensated CHF states.
Main Methods:
- Pharmacokinetic and pharmacodynamic assessment of oral furosemide in 11 CHF patients.
- Comparison of drug absorption parameters during decompensation versus after weight normalization.
- D-xylose absorption test to evaluate general intestinal absorption.
Main Results:
- Compensated patients showed a significant decrease in lag time and time to peak serum furosemide concentration compared to decompensated patients.
- Peak serum furosemide concentration increased by 29% in compensated patients.
- No significant changes were observed in furosemide absorption/elimination half-lives, AUC, or D-xylose absorption.
Conclusions:
- Decompensated congestive heart failure alters the absorption of oral furosemide.
- These absorption changes may affect treatment efficacy in CHF patients.
- Further research is needed to optimize furosemide dosing in heart failure.
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