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First case report of Corynebacterium minutissimum septic arthritis associated with an indwelling device

Samiha Akkaya1, Yusuf Emre Ozdemir1, Esra Ensaroglu1

  • 1Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Future Microbiology
|December 20, 2024
PubMed

Insights

This case report details the first instance of septic arthritis caused by Corynebacterium minutissimum. Prompt diagnosis and treatment, including catheter removal, led to full recovery, highlighting the importance of considering this pathogen in specific infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Rheumatology

Background:

  • Corynebacterium minutissimum typically causes erythrasma, a superficial skin infection.
  • Extracutaneous infections, though rare, include endocarditis, peritonitis, and bloodstream infections.

Purpose of the Study:

  • To report the first case of septic arthritis caused by Corynebacterium minutissimum.
  • To review invasive Corynebacterium minutissimum infections in the literature.
  • To emphasize the diagnostic importance of this bacterium in specific clinical contexts.

Main Methods:

  • Diagnosis confirmed via clinical presentation and microbiological analysis of joint fluid.
  • Infection suspected to be catheter-related due to patient's hemodialysis catheter.
  • Treatment involved antibiotics and removal of the infected catheter.

Main Results:

  • Successful treatment resulted in reduced joint inflammation (pain, swelling, warmth).
  • Acute-phase reactants significantly decreased, indicating resolution of infection.
  • The patient fully recovered after a four-week antibiotic course and catheter removal.

Conclusions:

  • Clinicians should consider Corynebacterium minutissimum in septic arthritis, especially in patients with indwelling devices.
  • Isolation of non-diphtheria Corynebacterium from sterile sites in symptomatic patients warrants attention.
  • This case underscores the pathogen's potential for rare but severe invasive infections.
Keywords:
Corynebacterium minutissimumCorynebacterium non-diftheriaeindwelling deviceinfectionseptic arthritis

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