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Updated: Jun 4, 2025

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
Published on: January 6, 2010
High pressure excursion in a radial design oxygenator.
Ashley Svec1, Tyler Eadie1, Brandon D'Aloiso1
1UPMC Presbyterian Perfusion, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
Oxygenator high-pressure (HPE) during cardiopulmonary bypass is often unrecognized due to lack of monitoring. This case study reviews HPE causes, patient risk factors, and mitigation strategies for improved patient outcomes.
Area of Science:
- Cardiopulmonary bypass
- Medical device technology
- Patient safety
Background:
- Oxygenator high-pressure (HPE) is a critical event during cardiopulmonary bypass (CPB) where oxygenator inlet pressure rises, limiting flow.
- HPE is often unrecognized as most perfusionists do not monitor oxygenator inlet pressure.
- The underlying causes and patient-specific risk factors for HPE are not fully understood.
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