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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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Lymphoma follow-up pathway: A 10-year study to guide practice.

Charlotte Ryan1, Dervla Kelly2, Rajnish K Gupta3

  • 1Cancer Services, University Hospital Limerick, Ireland.

European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society
|December 20, 2024
PubMed
Summary

Routine follow-up for lymphoma survivors rarely detects relapse, which is usually found via patient symptoms. Personalized care plans and direct access to services are recommended over indefinite surveillance for detecting recurrence.

Keywords:
Follow-upHodgkin lymphomaLymphomaNon-Hodgkin lymphomaRelapseSurveillanceSurvivorship

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Area of Science:

  • Oncology
  • Hematology
  • Clinical Medicine

Background:

  • Lymphoma survivors treated with curative intent undergo indefinite follow-up, often at physician's discretion.
  • Current surveillance protocols may not be optimal for detecting relapse in Diffuse Large B-cell Lymphoma (DLBCL) and Hodgkin Lymphoma (HL) patients.

Purpose of the Study:

  • To investigate the clinical, biochemical, and radiological presentation of DLBCL and HL patients at recurrence.
  • To determine if relapses were detected during scheduled follow-up appointments.

Main Methods:

  • Cross-sectional study of 226 DLBCL and HL patients on surveillance.
  • Statistical analysis of patient characteristics at recurrence.
  • Kaplan-Meier estimator used to assess time to recurrence.

Main Results:

  • Only 13% of patients relapsed, with 73% occurring within 5 years.
  • All relapses were detected at unscheduled appointments, primarily due to patient-reported symptoms (97%).

Conclusions:

  • Routine follow-up, especially beyond 5 years, lacks evidence for detecting relapse.
  • Survivorship benefits of routine visits should be considered.
  • Personalized follow-up pathways with direct access and clear care plans are recommended.