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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain.

Søren Nf Hostrup1, Suganthiya S Croosu2, Johan Røikjer3

  • 1Radiology Research Center, Department of Radiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Neuroscience
|December 20, 2024
PubMed
Summary

Brain imaging reveals reduced cortical thickness in individuals with type 1 diabetes, particularly those with painful diabetic peripheral neuropathy (DPN). This cortical thinning may be linked to neuropathic pain.

Keywords:
Cortical thicknessGyrificationMagnetic resonance imagingNeuropathic painSulcus depthType 1 diabetes

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Area of Science:

  • Neurology
  • Diabetology
  • Neuroimaging

Background:

  • Type 1 diabetes is associated with various complications, including diabetic peripheral neuropathy (DPN).
  • The central nervous system's structural changes in diabetes, especially concerning neuropathic pain, require further investigation.

Purpose of the Study:

  • To investigate surface brain morphometry in individuals with type 1 diabetes.
  • To specifically examine differences in brain structure related to painful diabetic peripheral neuropathy (DPN).

Main Methods:

  • Brain MRI scans were acquired from 56 individuals with type 1 diabetes (categorized by DPN status) and 20 healthy controls.
  • Analysis included global and regional cortical thickness, sulcus depth, and gyrification.
  • Associations with clinical data and pain levels were evaluated.

Main Results:

  • Globally reduced cortical thickness was observed in the combined diabetes group and the painful DPN group compared to controls.
  • Specific regions, including the middle frontal gyrus, showed reduced thickness in diabetes and painful DPN.
  • The postcentral gyrus exhibited reduced cortical thickness in painful DPN and reduced sulcus depth correlating with pain intensity.

Conclusions:

  • Cortical thinning is prevalent in the brain cortex of individuals with diabetes, especially those with painful DPN.
  • Altered morphometry of the postcentral gyrus may be implicated in the pathophysiology of neuropathic pain.
  • Assessing cortical morphometry is crucial for understanding central nervous system involvement in diabetes and painful DPN.