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A Teleoperated Robotic System-Assisted Percutaneous Transiliac-Transsacral Screw Fixation Technique

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Global collaboration between platform trials in surgery and anaesthesia.

James Glasbey¹, Steve A Webb², Trisha Peel³

¹Academic Department of Surgery, University of Birmingham, Birmingham, UK.

British Journal of Anaesthesia

|December 20, 2024

Summary

Adaptive platform trials accelerate evidence generation for medical treatments, overcoming resource limitations of traditional studies. These efficient trials are increasingly vital in surgery and anesthesia research.

Keywords:

adaptive trials anaesthesia collaborative research perioperative care platform trials surgery surgical site infection

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Area of Science:

Clinical Trials
Evidence-Based Medicine
Surgical Research

Background:

Large, randomized trials are crucial for evidence-based medicine but are resource-intensive, limiting the scope of clinical questions addressed.
The high cost and time commitment of traditional trials restrict the pace of medical advancement.

Purpose of the Study:

To highlight the efficiency and adaptability of platform trials in accelerating evidence generation.
To emphasize the growing adoption and opportunities for platform trials in surgery and anesthesia.

Main Methods:

Adaptive platform trials allow for rapid evaluation of multiple treatments.
These trials can dynamically modify study parameters based on accumulating data.

Main Results:

Platform trials have demonstrated success in delivering rapid evidence, notably during the COVID-19 pandemic.
Their adoption is expanding into surgical and anesthesia fields.

Conclusions:

Adaptive platform trials offer a faster, more resource-efficient approach to clinical research compared to traditional randomized trials.
Perioperative physicians are encouraged to engage in and collaborate on platform trials to advance evidence-based practice.