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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Updated: Jun 4, 2025

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

Invasive Candidiasis.

Julia A Schroeder¹, Cameron M Wilson¹, Peter G Pappas¹

¹The University of Alabama at Birmingham, 1900 University Boulevard, 223 THT, Birmingham, AL 35294, USA.

Infectious Disease Clinics of North America

|December 20, 2024

Summary

This summary is machine-generated.

Invasive candidiasis (IC), a serious fungal infection, can affect any organ. Early diagnosis and appropriate antifungal treatment are crucial for better patient outcomes and effective antifungal stewardship.

Keywords:

Antifungals Bloodstream infection Candida Fungal infection Invasive candidiasis

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Area of Science:

Mycology
Infectious Diseases
Clinical Medicine

Background:

Invasive candidiasis (IC) encompasses diverse syndromes caused by Candida species.
Candidemia is a common manifestation, but IC can impact any organ system, including visceral organs, vasculature, bones, joints, eyes, and the central nervous system.

Purpose of the Study:

To highlight the significance of Candida species in causing invasive infections.
To emphasize the importance of integrating advanced diagnostics with clinical assessment for managing IC.
To promote judicious use of antifungal therapies for improved patient outcomes.

Main Methods:

Review of current understanding of invasive candidiasis syndromes.
Discussion of diagnostic approaches and clinical assessment strategies.
Emphasis on antifungal stewardship principles.

Main Results:

Candida species are significant global pathogens causing a spectrum of invasive infections.
Effective management hinges on early detection and appropriate antifungal interventions.
Optimizing diagnostic and therapeutic strategies is key to antifungal stewardship.

Conclusions:

Invasive candidiasis requires a comprehensive approach involving diagnostics, clinical evaluation, and targeted antifungal therapy.
Judicious use of antifungals and advanced diagnostics improves patient outcomes.
Effective antifungal stewardship is essential for combating invasive Candida infections.