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Chronobiological variations of acute aortic dissection in a Northwest Chinese population

Ermek Tangsakar1, Rinat Imamu1, Aybek Nabi1

  • 1Heart and Panvascular Diseases Medicine Treatment Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, People's Republic of China.

Journal of Cardiothoracic Surgery
|December 20, 2024
PubMed

Insights

Acute aortic dissection (AAD) shows seasonal and daily patterns in northwest China. Onset peaks in winter evenings (19:00-24:00), highlighting chronobiological influences on AAD occurrence.

Area of Science:

  • Cardiology
  • Chronobiology
  • Public Health

Background:

  • Acute aortic dissection (AAD) prevalence is rising globally.
  • Understanding circadian variations in AAD onset is crucial for prevention strategies.
  • This study focuses on a northwest Chinese population.

Purpose of the Study:

  • To investigate the circadian variations in AAD onset.
  • To identify peak seasons and times for AAD occurrence.
  • To provide insights for AAD prevention based on chronobiological patterns.

Main Methods:

  • Retrospective analysis of clinical data from 1,145 AAD patients (2010-2020).
  • Examination of periodic features, including seasonal and daily onset patterns.
  • Statistical analysis of Stanford type A and type B AAD distributions.

Main Results:

  • AAD incidence was highest in winter (31.27%) and lowest in summer (19.65%).
  • Peak AAD occurrence was observed between 19:00-24:00 (28.03%), with the lowest between 1:00-6:00 (21.57%).
  • Significant differences in seasonal and daily distribution were noted between Stanford type A and type B AAD.

Conclusions:

  • AAD onset exhibits a distinct chronobiological pattern in northwest China.
  • Winter and the 19:00-24:00 time window represent peak periods for AAD.
  • Findings support the need for time-specific AAD prevention measures.
Abstract

Keywords:
Acute aortic dissectionChronobiological patternsIncidence rateNorthwest China

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