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Systemic lupus erythematosus is a risk factor for having multiple subtypes of cutaneous lupus erythematosus

Grace Lu1, Larry Steven Brown2, Benjamin F Chong1,2

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Lupus
|December 21, 2024
PubMed

Insights

Nearly one in five patients with cutaneous lupus erythematosus (CLE) develop multiple subtypes. Systemic lupus erythematosus (SLE) diagnosis is a significant risk factor for developing multiple CLE subtypes.

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Cutaneous lupus erythematosus (CLE) can manifest in various subtypes.
  • Understanding the prevalence and risk factors for multiple CLE subtypes is limited.

Purpose of the Study:

  • To determine the frequency of multiple CLE subtypes.
  • To identify risk factors associated with multiple CLE diagnoses.

Main Methods:

  • Cross-sectional study of 319 CLE patients from a specialized registry.
  • Data collected included demographics and clinical information.
  • Univariate and multivariable logistic regression analyses were performed.

Main Results:

  • 18.5% of patients had two or more CLE subtypes.
  • Multiple subtypes were associated with systemic lupus erythematosus (SLE) diagnosis, positive anti-nuclear antibody, arthritis, renal disorder, and serositis.
  • SLE diagnosis remained a significant factor in multivariable analysis.

Conclusions:

  • Almost one-fifth of CLE patients present with multiple subtypes.
  • SLE diagnosis is a key risk factor for multiple CLE subtypes.
  • Clinicians should monitor CLE patients for subtype progression and associated systemic conditions.
Abstract

Keywords:
Cutaneous lupus erythematosussystemic lupus erythematosus

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