Enhancing Equity in Genomics: Incorporating Measures of Structural Racism, Discrimination, and Social Determinants of...

Area of Science:

• Genomics
• Social Epidemiology
• Health Equity

Background:

• Structural racism and discrimination are significant social determinants of health.
• Existing genetic studies of complex diseases often lack measures for these societal harms.
• This gap limits the understanding of genetic and environmental interactions in racialized populations.

Purpose of the Study:

• To propose methodologies for integrating measures of structural racism and discrimination into genetic analyses.
• To enhance the accuracy and utility of genetic findings for diverse populations.
• To promote equity in genomics and precision health research.

Main Methods:

• Drawing on insights from social sciences and public health.
• Developing and incorporating novel measurement tools for structural racism and discrimination.
• Integrating these measures within genetic study designs for complex diseases.

Main Results:

• Inclusion of these measures can strengthen genetic study findings.
• It may clarify complex gene-environment interactions in a racialized context.
• This approach supports greater equity in genomics and precision health.

Conclusions:

• Integrating social determinants like structural racism is crucial for robust genetic research.
• This methodology can foster collaborations and community-centered research.
• It advances the goals of genomics and precision health for improved public health outcomes.